Semaglutide
Also known as: Wegovy, Ozempic, Rybelsus
Browse our Semaglutide articles and comparisons. Choose a comparison or related article below for the evidence behind each topic.
Profile at a glance
| Attribute | Value |
|---|---|
| Sponsor | Novo Nordisk |
| Mechanism | GLP-1 receptor agonist |
| Administration | Once-weekly subcutaneous injection (Wegovy/Ozempic); once-daily oral tablet (Rybelsus; Wegovy pill approved Dec 2025) |
| Peak weight loss | ~15–17% at 68 weeks (STEP program) |
| Status | FDA-approved |
Semaglutide compared
Comparisons involving Semaglutide, with the limits of comparing separate trials.
Retatrutide vs Mounjaro vs Ozempic
Mounjaro and Ozempic are diabetes brands; Zepbound and Wegovy have weight-management indications. Compare their evidence with investigational retatrutide.
Updated September 8, 2026
Retatrutide vs Wegovy: Triple Agonist vs GLP-1
Wegovy is approved in oral and injectable forms, including Wegovy HD. Retatrutide remains investigational with no completed direct comparison.
Updated September 8, 2026
Zepbound vs Wegovy: Which One Actually Works Better in 2026?
Zepbound produced -20.2% vs Wegovy's -13.7% weight loss in the SURMOUNT-5 head-to-head trial. Full comparison of cost, side effects, and CV data.
Updated September 8, 2026
Tirzepatide vs Semaglutide: Complete Comparison (2026 Data)
Tirzepatide vs semaglutide with SURMOUNT-5 head-to-head data: -20.2% vs -13.7% weight loss. Full comparison of efficacy, side effects, and access.
Updated September 8, 2026
Mounjaro vs Ozempic: Which Is Better for Weight Loss and Diabetes?
Mounjaro outperformed injected Ozempic 1 mg in SURPASS-2. Compare the actual trial doses, current formulations, organ-risk indications and coverage.
Updated September 8, 2026
Ozempic vs Wegovy: Same Drug, Different Purpose
Same active ingredient, different product labels: Ozempic and Wegovy injections and tablets, including Wegovy HD.
Updated September 8, 2026
Peptides for Weight Loss vs GLP-1 Drugs: What the Evidence Says
Peptide chemistry does not establish efficacy. What trials show for semaglutide, tirzepatide, retatrutide and other marketed peptides.
Updated September 8, 2026
Orforglipron vs Rybelsus (Oral Semaglutide): Two Oral GLP-1 Pills Compared
Foundayo is approved for adult weight management; Rybelsus has diabetes-related uses. Compare fasting rules and the limits of ACHIEVE-3.
Updated September 8, 2026
Related articles
Safety, mechanism, and context pieces that reference Semaglutide.
GLP-1 vs GLP-2 vs GLP-3: What's the Difference?
GLP-1 and GLP-2 are real hormones. "GLP-3" is not — it's slang for retatrutide. Here's what each term actually means.
Updated September 8, 2026
Switching to Retatrutide from Tirzepatide or Semaglutide
No validated conversion or routine-care washout exists. What current trials and approval status mean for a possible switch.
Updated September 8, 2026
What Is CagriSema? Novo Nordisk's Amylin + GLP-1 Weight Loss Combination
The investigational cagrilintide–semaglutide combination: REDEFINE results, side effects and the status of FDA review.
Updated September 8, 2026
See all drug profiles in the drug profiles hub or compare drugs head-to-head in the comparisons hub.