Orforglipron (Foundayo): Drug Profile
Also known as: Foundayo
Browse our Orforglipron (Foundayo) articles and comparisons. Start with the drug explainer for the mechanism and trial evidence, or choose a comparison below.
Profile at a glance
| Attribute | Value |
|---|---|
| Sponsor | Eli Lilly |
| Mechanism | GLP-1 receptor agonist (non-peptide small molecule) |
| Administration | Once-daily oral pill — no food or water restrictions |
| Peak weight loss | ~12.4% at 72 weeks (ATTAIN-1) |
| Status | FDA-approved April 2026 — first non-peptide oral GLP-1 agonist |
Where is the oral titration schedule?
The daily-pill schedule is on the Foundayo explainer (card below) — this profile does not repeat the dose table.
Drug explainer
Foundayo (Orforglipron): Lilly's Oral GLP-1 Pill Explained →Foundayo is Lilly’s approved daily oral GLP-1 medicine. FDA trial results, dosing, side effects and dose-specific US savings terms explained.
Orforglipron (Foundayo) compared
Comparisons involving Orforglipron (Foundayo), with the limits of comparing separate trials.
Orforglipron vs Tirzepatide (Zepbound): Oral Pill vs Weekly Injection
Daily Foundayo and weekly tirzepatide have different labeled uses. Separate trials do not prove that one is twice as effective.
Updated September 8, 2026
Orforglipron vs Zepbound (Tirzepatide): Daily Pill vs Weekly Injection
Foundayo and Zepbound are approved weight-management options. Compare current offers, coverage, trial results and possible regain after switching.
Updated September 8, 2026
Retatrutide vs Orforglipron: Injectable Triple Agonist vs Oral GLP-1
Foundayo (orforglipron) is FDA-approved; retatrutide is investigational. Compare their routes, trial evidence, and safety limits.
Updated September 8, 2026
Orforglipron vs Rybelsus (Oral Semaglutide): Two Oral GLP-1 Pills Compared
Foundayo is approved for adult weight management; Rybelsus has diabetes-related uses. Compare fasting rules and the limits of ACHIEVE-3.
Updated September 8, 2026
Related articles
Safety, mechanism, and context pieces that reference Orforglipron (Foundayo).
Retatrutide Pill vs Injection: Is There an Oral Formulation?
Retatrutide has no approved pill or injection. Foundayo and oral Wegovy are different approved medicines.
Updated September 8, 2026
NBC TODAY on Foundayo (Oral GLP-1 Pill): Fact Check
TODAY’s Foundayo segment checked against FDA information, with the automated drug-name discrepancy kept separate from verified claims.
Updated September 8, 2026
See all drug profiles in the drug profiles hub or compare drugs head-to-head in the comparisons hub.