Amycretin (zenagamtide)

Also known as: zenagamtide

Profile at a glance

AttributeValue
SponsorNovo Nordisk
MechanismUnimolecular GLP-1 + amylin dual agonist
AdministrationOnce-daily oral tablet OR once-weekly subcutaneous injection
Peak weight loss~22% subq at 36 weeks / ~13.1% oral at 12 weeks (Phase 1)
StatusPhase 3 for obesity initiated Q1 2026

Deep dive

What Is Amycretin? Novo Nordisk's Oral GLP-1/Amylin Weight Loss Drug

Novo Nordisk's first-in-class GLP-1/amylin dual agonist — 13.1% weight loss as a daily pill in 12 weeks, 22% as a weekly injection in 36 weeks.

See all drug profiles in the drug profiles hub or compare drugs head-to-head in the comparisons hub.